Adjuvant Therapies of Cancer

Nonfiction, Health & Well Being, Medical, Specialties, Radiology & Nuclear Medicine, Oncology
Cover of the book Adjuvant Therapies of Cancer by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642816857
Publisher: Springer Berlin Heidelberg Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9783642816857
Publisher: Springer Berlin Heidelberg
Publication: December 6, 2012
Imprint: Springer
Language: English

Transplantation of syngeneic (donor is a monozygous twin) or allogeneic (donor is an HLA-identical sibling) marrow provides the opportunity for aggressive antileukemic therapy without regard to marrow toxicity. Until 1975, marrow transplantation was carried out only after failure of all other therapy. Consequently, most patients were in advanced relapse. Six of 16 recipients of syngeneic marrow and 13 of 100 recipients of allogeneic marrow are still in remission after 5. 5-10 years [3, 7]. An actuarial survival curve of the first 100 patients grafted in Seattle after conditioning with cyclophos­ phamide (60 mg/kg on each of 2 successive days) and total body irradiation (1,000 rad) showed three periods of interest: (1) The first 4 months showed a rapid loss of patients associated with advanced illness, graft-versus-host disease, infections (in particular interstitial pneumonias), and recurrent leukemia; (2) from 4 months to 2 years, the curve showed a much slower rate of decline attributable primarily to recurrent leukemia; and (3) from 2-10 years, the curve was almost flat with a negligible loss of patients and no recurrent leukemia. This flat portion of the curve corresponded to 13% of the patients and indicates a strong probability that the majority of these survivors are cured of their disease [8]. Attempts at reducing the incidence of leukemic relapse after transplantation were made by a number of marrow transplant groups by added chemotherapy.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Transplantation of syngeneic (donor is a monozygous twin) or allogeneic (donor is an HLA-identical sibling) marrow provides the opportunity for aggressive antileukemic therapy without regard to marrow toxicity. Until 1975, marrow transplantation was carried out only after failure of all other therapy. Consequently, most patients were in advanced relapse. Six of 16 recipients of syngeneic marrow and 13 of 100 recipients of allogeneic marrow are still in remission after 5. 5-10 years [3, 7]. An actuarial survival curve of the first 100 patients grafted in Seattle after conditioning with cyclophos­ phamide (60 mg/kg on each of 2 successive days) and total body irradiation (1,000 rad) showed three periods of interest: (1) The first 4 months showed a rapid loss of patients associated with advanced illness, graft-versus-host disease, infections (in particular interstitial pneumonias), and recurrent leukemia; (2) from 4 months to 2 years, the curve showed a much slower rate of decline attributable primarily to recurrent leukemia; and (3) from 2-10 years, the curve was almost flat with a negligible loss of patients and no recurrent leukemia. This flat portion of the curve corresponded to 13% of the patients and indicates a strong probability that the majority of these survivors are cured of their disease [8]. Attempts at reducing the incidence of leukemic relapse after transplantation were made by a number of marrow transplant groups by added chemotherapy.

More books from Springer Berlin Heidelberg

Cover of the book Aspect-Oriented Database Systems by
Cover of the book Soil Degradable Bioplastics for a Sustainable Modern Agriculture by
Cover of the book Production-oriented and Comprehension-based Grammar Teaching in the Foreign Language Classroom by
Cover of the book Integrierte Industrielle Sach- und Dienstleistungen by
Cover of the book Optimal Time-Domain Noise Reduction Filters by
Cover of the book Besonderheiten der Sportbetriebslehre by
Cover of the book Advances in Cryptology -- CRYPTO 2015 by
Cover of the book Evidenzbasierung in der Suchtprävention by
Cover of the book Bismuth-Mediated Organic Reactions by
Cover of the book Lung Cancer by
Cover of the book Early Development of the Shoulder Girdle and Sternum in Marsupials (Mammalia: Metatheria) by
Cover of the book Diabetes-Handbuch by
Cover of the book Praxis der Funktionalen Stimmtherapie by
Cover of the book Amorphous Nanophotonics by
Cover of the book Reviews of Physiology, Biochemistry and Pharmacology 159 by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy