ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

Applications in Drug Discovery and Development

Nonfiction, Health & Well Being, Medical, Medical Science, Biotechnology, Science & Nature, Science, Biological Sciences, Biochemistry, Pharmacology
Cover of the book ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins by Honghui Zhou, Frank-Peter Theil, Wiley
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Author: Honghui Zhou, Frank-Peter Theil ISBN: 9781118898741
Publisher: Wiley Publication: October 26, 2015
Imprint: Wiley Language: English
Author: Honghui Zhou, Frank-Peter Theil
ISBN: 9781118898741
Publisher: Wiley
Publication: October 26, 2015
Imprint: Wiley
Language: English

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs.

• Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs
• Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective
• Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines
• Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan
• Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs.

• Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs
• Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective
• Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines
• Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan
• Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

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