Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta, Elsevier Science
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Surendra Nimesh, Ramesh Chandra, Nidhi Gupta ISBN: 9780081005637
Publisher: Elsevier Science Publication: April 4, 2017
Imprint: Woodhead Publishing Language: English
Author: Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
ISBN: 9780081005637
Publisher: Elsevier Science
Publication: April 4, 2017
Imprint: Woodhead Publishing
Language: English

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. 

The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.

  • Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies
  • Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc.
  • Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. 

The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.

More books from Elsevier Science

Cover of the book Carbon-13 NMR Spectroscopy of Biological Systems by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Handbook of Organic Materials for Electronic and Photonic Devices by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Advances in Cancer Research by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Geomorphology of Central America by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Fetal and Neonatal Disorders by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Cilia, Part A by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Spontaneous Animal Models of Human Disease by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Creep-Resistant Steels by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Advances in Agronomy by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Enological Chemistry by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book The China Business Model by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Color Trends and Selection for Product Design by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Nanoscience and its Applications by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Applications of ATILA FEM Software to Smart Materials by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
Cover of the book Op Amp Applications Handbook by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy