Antineoplastic Drugs

Organic Syntheses

Nonfiction, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Antineoplastic Drugs by Daniel Lednicer, Wiley
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Daniel Lednicer ISBN: 9781118892565
Publisher: Wiley Publication: March 11, 2015
Imprint: Wiley Language: English
Author: Daniel Lednicer
ISBN: 9781118892565
Publisher: Wiley
Publication: March 11, 2015
Imprint: Wiley
Language: English

The past decade has seen a significant increase of research aimed at discovering new drugs for treating cancer, and the increasing number of new antineoplastic drugs approved by regulatory agencies reflects this. Until now, details on the synthesis of these newer agents have been scattered in various journals and in US and European patents. This timely volume deals with the organic chemistry involved in the synthesis of the agents found within antineoplastic drugs, including descriptions of the synthetic schemes for the preparation of over 200 compounds that have been granted non-proprietary names. Compounds are collected in chapters based on the mechanism of action rather than on their chemical structures. Each individual chapter is preceded by a brief description of that mechanism and includes detailed flow charts of the preparation of those compounds accompanied by discussions of the organic chemistry involved in each step. The first half of this volume is dedicated to the syntheses of established chemotherapy drugs. Kinase inhibitors occupy the following chapters with the largest single chapter dealing with the fifty compounds that inhibit tyrosine kinase. This class stands out since over twenty compounds in this group have been approved for treating patients; a rare track record compared to any other class of therapeutic agents. Antineoplastic Drugs: Organic Syntheses is written to appeal to organic and medicinal chemists in industry and academia. It is beneficial to those composing grant proposals for NCI and related organizations. The book is accessible to advanced undergraduates as well as graduates and researchers as well as those with a thorough grasp of organic chemistry.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The past decade has seen a significant increase of research aimed at discovering new drugs for treating cancer, and the increasing number of new antineoplastic drugs approved by regulatory agencies reflects this. Until now, details on the synthesis of these newer agents have been scattered in various journals and in US and European patents. This timely volume deals with the organic chemistry involved in the synthesis of the agents found within antineoplastic drugs, including descriptions of the synthetic schemes for the preparation of over 200 compounds that have been granted non-proprietary names. Compounds are collected in chapters based on the mechanism of action rather than on their chemical structures. Each individual chapter is preceded by a brief description of that mechanism and includes detailed flow charts of the preparation of those compounds accompanied by discussions of the organic chemistry involved in each step. The first half of this volume is dedicated to the syntheses of established chemotherapy drugs. Kinase inhibitors occupy the following chapters with the largest single chapter dealing with the fifty compounds that inhibit tyrosine kinase. This class stands out since over twenty compounds in this group have been approved for treating patients; a rare track record compared to any other class of therapeutic agents. Antineoplastic Drugs: Organic Syntheses is written to appeal to organic and medicinal chemists in industry and academia. It is beneficial to those composing grant proposals for NCI and related organizations. The book is accessible to advanced undergraduates as well as graduates and researchers as well as those with a thorough grasp of organic chemistry.

More books from Wiley

Cover of the book Coaching Basketball For Dummies, Mini Edition by Daniel Lednicer
Cover of the book Formal Methods Applied to Industrial Complex Systems by Daniel Lednicer
Cover of the book World History For Dummies by Daniel Lednicer
Cover of the book Contemporary Archaeology in Theory by Daniel Lednicer
Cover of the book Predictive Control in Process Engineering by Daniel Lednicer
Cover of the book A Non-Freaked Out Guide to Teaching the Common Core by Daniel Lednicer
Cover of the book Meeting Excellence by Daniel Lednicer
Cover of the book The Failure of Risk Management by Daniel Lednicer
Cover of the book Wiley GAAP Codification Enhanced by Daniel Lednicer
Cover of the book Public Participation for 21st Century Democracy by Daniel Lednicer
Cover of the book Sieben und Siebmaschinen by Daniel Lednicer
Cover of the book Introduction to Graphic Design Methodologies and Processes by Daniel Lednicer
Cover of the book Fundamental Principles of Polymeric Materials by Daniel Lednicer
Cover of the book Real Estate Dangers and How to Avoid Them by Daniel Lednicer
Cover of the book The Idea of Culture by Daniel Lednicer
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy