Autophagy of the Nervous System

Cellular Self-Digestion in Neurons and Neurological Diseases

Nonfiction, Science & Nature, Science, Biological Sciences, Cytology
Cover of the book Autophagy of the Nervous System by Zhenyu Yue, Charleen T Chu, World Scientific Publishing Company
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Zhenyu Yue, Charleen T Chu ISBN: 9789814440684
Publisher: World Scientific Publishing Company Publication: October 1, 2012
Imprint: WSPC Language: English
Author: Zhenyu Yue, Charleen T Chu
ISBN: 9789814440684
Publisher: World Scientific Publishing Company
Publication: October 1, 2012
Imprint: WSPC
Language: English

What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy.

More books from World Scientific Publishing Company

Cover of the book Etale Cohomology Theory by Zhenyu Yue, Charleen T Chu
Cover of the book Biocatalysis by Zhenyu Yue, Charleen T Chu
Cover of the book An Introduction to Differential Equations by Zhenyu Yue, Charleen T Chu
Cover of the book An Undergraduate Introduction to Financial Mathematics by Zhenyu Yue, Charleen T Chu
Cover of the book How to Succeed in Breastfeeding Without Really Trying, or Ten Steps to Laugh Your Way Through by Zhenyu Yue, Charleen T Chu
Cover of the book Modeling and Pricing in Financial Markets for Weather Derivatives by Zhenyu Yue, Charleen T Chu
Cover of the book Searching for the Best Medicine by Zhenyu Yue, Charleen T Chu
Cover of the book Migration in East and Southeast Asia by Zhenyu Yue, Charleen T Chu
Cover of the book Global Financial Crisis and Challenges for China by Zhenyu Yue, Charleen T Chu
Cover of the book Clinical Handbook of Chinese Medicine by Zhenyu Yue, Charleen T Chu
Cover of the book Experimental Studies of Neutrino Oscillations by Zhenyu Yue, Charleen T Chu
Cover of the book Negotiation Excellence by Zhenyu Yue, Charleen T Chu
Cover of the book Edward Teller Lectures by Zhenyu Yue, Charleen T Chu
Cover of the book 50 Years of ASEAN and Singapore by Zhenyu Yue, Charleen T Chu
Cover of the book Seeking Adam Smith by Zhenyu Yue, Charleen T Chu
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy