Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Endocrinology & Metabolism, Oncology
Cover of the book Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319518909
Publisher: Springer International Publishing Publication: April 19, 2017
Imprint: Springer Language: English
Author:
ISBN: 9783319518909
Publisher: Springer International Publishing
Publication: April 19, 2017
Imprint: Springer
Language: English

This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches.

*Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma *is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.      

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches.

*Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma *is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.      

More books from Springer International Publishing

Cover of the book Green City Planning and Practices in Asian Cities by
Cover of the book Evolutionary Computation in Combinatorial Optimization by
Cover of the book Reversible Computation by
Cover of the book Handbook of Genetic Programming Applications by
Cover of the book The New World of Utilities by
Cover of the book Integrated Community-Managed Development by
Cover of the book Climate Change Adaptation in Eastern Europe by
Cover of the book Membrane Organization and Dynamics by
Cover of the book Stories of Identity among Black, Middle Class, Second Generation Caribbeans by
Cover of the book Green, Pervasive, and Cloud Computing by
Cover of the book Web Services and Formal Methods by
Cover of the book Urban Planning for Healthy European Cities by
Cover of the book The Economy of South Asia by
Cover of the book Nomic Truth Approximation Revisited by
Cover of the book Applied Regression Analysis for Business by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy