Biochemistry and Genetics of Recq-Helicases

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Science & Nature, Science, Biological Sciences, Evolution
Cover of the book Biochemistry and Genetics of Recq-Helicases by David B. Lombard, Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: David B. Lombard ISBN: 9781461514053
Publisher: Springer US Publication: December 6, 2012
Imprint: Springer Language: English
Author: David B. Lombard
ISBN: 9781461514053
Publisher: Springer US
Publication: December 6, 2012
Imprint: Springer
Language: English

Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.

More books from Springer US

Cover of the book The Practice of Coronary Artery Bypass Surgery by David B. Lombard
Cover of the book Morality, Ethics, and Gifted Minds by David B. Lombard
Cover of the book The Early Identification of Language Impairment in Children by David B. Lombard
Cover of the book The Science of Life by David B. Lombard
Cover of the book Dynamics of Visual Motion Processing by David B. Lombard
Cover of the book Retail Supply Chain Management by David B. Lombard
Cover of the book Perfecting Social Skills by David B. Lombard
Cover of the book Alternative and Complementary Therapies for Cancer by David B. Lombard
Cover of the book Gastrointestinal Oncology by David B. Lombard
Cover of the book Biogeochemistry of Global Change by David B. Lombard
Cover of the book Forensic Neuropsychology by David B. Lombard
Cover of the book Philosophy, Children, and the Family by David B. Lombard
Cover of the book Clinical Applications of Cytokines and Growth Factors by David B. Lombard
Cover of the book Thyroid Ultrasound and Ultrasound-Guided FNA Biopsy by David B. Lombard
Cover of the book Understanding Psychological Testing in Children by David B. Lombard
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy