Biomolecular Forms and Functions

A Celebration of 50 Years of the Ramachandran Map

Nonfiction, Science & Nature, Science, Biological Sciences, Cytology, Computers
Cover of the book Biomolecular Forms and Functions by Manju Bansal, N Srinivasan, World Scientific Publishing Company
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Author: Manju Bansal, N Srinivasan ISBN: 9789814449151
Publisher: World Scientific Publishing Company Publication: December 13, 2012
Imprint: WSPC/IIS Language: English
Author: Manju Bansal, N Srinivasan
ISBN: 9789814449151
Publisher: World Scientific Publishing Company
Publication: December 13, 2012
Imprint: WSPC/IIS
Language: English

Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules.

Contents:

  • The Legacy of G N Ramachandran and the Development of Structural Biology in India (M Vijayan)
  • The Open-Ended Intellectual Legacy of GNR (George Rose)
  • The Ramachandran Plot and Protein Structure Validation (Roman A Laskowski, Nicholas Furnham and Janet M Thornton)
  • Analysis of Dihedral Angle Variability in Related Protein Structures (Shekhar C Mande, Ashwani Kumar and Payel Ghosh)
  • Multiprotein Assemblies: Modulating Cell Activity Through Targeting Protein-Protein Interfaces (Alicia P Higueruelo, Harry Jubb and Tom L Blundell)
  • Computational Approaches for Understanding the Recognition Mechanism of Protein Complexes (M Michael Gromiha)
  • Cold-Shock Domains — Versatile Molecular Modules for Single-Stranded RNA Binding and Remodeling (Florian Mayr and Udo Heinemann)
  • Protein Disulfide Analysis and Design (Siddharth Patel, S Indu, C Ramakrishnan and Raghavan Varadarajan)
  • Controlling Conformational Dynamics to Modulate Protein Function (Shahir S Rizk, Marcin Paduch and Anthony A Kossiakoff)
  • Structural Bioinformatics Approaches for Deciphering Biosynthetic Code of Secondary Metabolites (Shradha Khater and Debasisa Mohanty)
  • The Inherent Structure Landscape of Met–Enkephalin Determined by the MOLS Technique (N Balaji, L Ramya and N Gautham)
  • and other papers

Readership: Practicing researchers in academia and industry.
Key Features:

  • Authors are eminent scientists with well-cited research in structural and computational biology
  • The book includes articles covering results obtained using the latest structural biology techniques
  • The book covers important areas in the fields of protein folding, association, function and design
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Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules.

Contents:

Readership: Practicing researchers in academia and industry.
Key Features:

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