Biomolecular Imaging at High Spatial and Temporal Resolution In Vitro and In Vivo

Nonfiction, Science & Nature, Science, Chemistry, Analytic, Biological Sciences
Cover of the book Biomolecular Imaging at High Spatial and Temporal Resolution In Vitro and In Vivo by Thomas Harry Sharp, Springer International Publishing
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Author: Thomas Harry Sharp ISBN: 9783319021591
Publisher: Springer International Publishing Publication: October 31, 2013
Imprint: Springer Language: English
Author: Thomas Harry Sharp
ISBN: 9783319021591
Publisher: Springer International Publishing
Publication: October 31, 2013
Imprint: Springer
Language: English

As part of a collaboration between two different groups in chemistry and biochemistry, Thom Sharp presents here his thesis work on the development of new methods for cryoelectron microscopy. Throughout his Ph.D., Thom had to master a whole range of techniques including modelling, molecular biology and microscopy. Using these skills to tackle an outstanding problem, the pursuit of high-resolution structures of peptide-based materials, Thom highlights in this thesis his newly developed methods for analysing and processing this particular type of electron microscopy data. This thesis gives the first molecular description of a de-novo designed peptide-based material. In general, this research will have a huge impact on the peptide assembly field, and also in electron microscopy as it introduces new methods and approaches, all of which are Thom's inventions and are described in this thesis.

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As part of a collaboration between two different groups in chemistry and biochemistry, Thom Sharp presents here his thesis work on the development of new methods for cryoelectron microscopy. Throughout his Ph.D., Thom had to master a whole range of techniques including modelling, molecular biology and microscopy. Using these skills to tackle an outstanding problem, the pursuit of high-resolution structures of peptide-based materials, Thom highlights in this thesis his newly developed methods for analysing and processing this particular type of electron microscopy data. This thesis gives the first molecular description of a de-novo designed peptide-based material. In general, this research will have a huge impact on the peptide assembly field, and also in electron microscopy as it introduces new methods and approaches, all of which are Thom's inventions and are described in this thesis.

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