Biotransformation and Metabolite Elucidation of Xenobiotics

Characterization and Identification

Nonfiction, Science & Nature, Science, Biological Sciences, Biotechnology
Cover of the book Biotransformation and Metabolite Elucidation of Xenobiotics by , Wiley
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781118097779
Publisher: Wiley Publication: March 23, 2011
Imprint: Wiley Language: English
Author:
ISBN: 9781118097779
Publisher: Wiley
Publication: March 23, 2011
Imprint: Wiley
Language: English

The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity.

The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. Also, strategies for dealing with reactive intermediates in drug discovery and development are presented as well as case studies on improving the decision-making process in the structural modification of drug candidates. The last chapter discusses the regulatory perspectives of safety testing of drug metabolites and why, how, and when to test their safety.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity.

The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. Also, strategies for dealing with reactive intermediates in drug discovery and development are presented as well as case studies on improving the decision-making process in the structural modification of drug candidates. The last chapter discusses the regulatory perspectives of safety testing of drug metabolites and why, how, and when to test their safety.

More books from Wiley

Cover of the book Designing Rainwater Harvesting Systems by
Cover of the book Marine Algae Extracts, 2 Volume Set by
Cover of the book Ancient Judaism by
Cover of the book Free Space Optical Systems Engineering by
Cover of the book An Introduction to Seismology, Earthquakes, and Earth Structure by
Cover of the book Cloud Security by
Cover of the book The Science of Occupational Health by
Cover of the book Hacking Wireless Networks For Dummies by
Cover of the book Switch Off by
Cover of the book The Elements of Continuum Biomechanics by
Cover of the book Photovoltaic Power System by
Cover of the book Becoming a Marriage and Family Therapist by
Cover of the book The Value of Privacy by
Cover of the book It's Who You Know by
Cover of the book 12 Simple Secrets Real Moms Know by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy