Blood Cell Biochemistry

Hematopoietic Cell Growth Factors and Their Receptors

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Hematology, Oncology
Cover of the book Blood Cell Biochemistry by , Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9780585317281
Publisher: Springer US Publication: August 31, 1996
Imprint: Springer Language: English
Author:
ISBN: 9780585317281
Publisher: Springer US
Publication: August 31, 1996
Imprint: Springer
Language: English

Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon­ strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down­ stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog­ ical situations (see below).

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon­ strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down­ stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog­ ical situations (see below).

More books from Springer US

Cover of the book Mental Health Interventions with Preschool Children by
Cover of the book The Toxicant Induction of Irritant Asthma, Rhinitis, and Related Conditions by
Cover of the book Minimally Processed Refrigerated Fruits and Vegetables by
Cover of the book The Cancer Patient and Supportive Care by
Cover of the book Novel Angiogenic Mechanisms by
Cover of the book Parent-Child Interaction by
Cover of the book Ecological Risk Assessment of Contaminants in Soil by
Cover of the book Chest Pain with Normal Coronary Angiograms: Pathogenesis, Diagnosis and Management by
Cover of the book Blood Oxygenation by
Cover of the book Nonlinear Filtering and Optimal Phase Tracking by
Cover of the book Systems Science by
Cover of the book Advances in Clinical Child Psychology by
Cover of the book Advances in Cryogenic Engineering Materials by
Cover of the book The Social and Economic Impact of New Technology 1978–84: A Select Bibliography by
Cover of the book Handbook of Occupational Health and Wellness by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy