Cancer Genome and Tumor Microenvironment

Nonfiction, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Cancer Genome and Tumor Microenvironment by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781441907110
Publisher: Springer New York Publication: January 23, 2010
Imprint: Springer Language: English
Author:
ISBN: 9781441907110
Publisher: Springer New York
Publication: January 23, 2010
Imprint: Springer
Language: English

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.

More books from Springer New York

Cover of the book Cellular Signaling in Health and Disease by
Cover of the book Current Perspectives on the Archaeology of African Slavery in Latin America by
Cover of the book Systems Biology of RNA Binding Proteins by
Cover of the book Challenging Cases in Rheumatology and Diseases of the Immune System by
Cover of the book Central Functions of the Ghrelin Receptor by
Cover of the book Atlas of Conducted Electrical Weapon Wounds and Forensic Analysis by
Cover of the book Handbook of Gender Research in Psychology by
Cover of the book Pathology by
Cover of the book Digital Fingerprinting by
Cover of the book 3D Integration for NoC-based SoC Architectures by
Cover of the book Neurobiology of Actin by
Cover of the book Extrasynaptic GABAA Receptors by
Cover of the book Amputation, Prosthesis Use, and Phantom Limb Pain by
Cover of the book Affect and Mathematical Problem Solving by
Cover of the book Bladder Dysfunction in the Adult by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy