Cell Death and Diseases of the Nervous System

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neurology
Cover of the book Cell Death and Diseases of the Nervous System by , Humana Press
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461216025
Publisher: Humana Press Publication: December 6, 2012
Imprint: Humana Language: English
Author:
ISBN: 9781461216025
Publisher: Humana Press
Publication: December 6, 2012
Imprint: Humana
Language: English

It is an honor to be asked to write a foreword for this timely book, which assembles contributions from authorities working in the area of pathological nervous system cell death, and has been expertly edited by Vassilis Koliatsos and Rajiv Ratan. That the inap­ propriate demise of brain or spinal cord cells is at the root of many neurological diseases has been appreciated since the early days of microscopic neuropathology, but it has only been in the last decade or so that pervasive therapeutic nihilism has lifted. In the journey of medical progress, we have reached the shores of a marvelous new land. Three major scientific thrusts in particular have converged to produce the press of ideas covered here. First, burgeoning information about the fundamental nature of central nervous system cell--(;ell signaling, both the fast signaling mediated by conventional neu­ rotransmitters and the usually slower signaling mediated by neuromodulators and growth factors. A central theme emerging in recent years has been the duality of these signaling mechanisms, which serve the nervous system in health, but which can become the very mediators of neuronal or glial cell degeneration in disease settings. Glutamate-mediated neurotransmission and excitotoxicity have been the defining and best-studied examples, but many other examples have also emerged. Second, delineation of the molecular under­ pinnings of programmed cell death, and an appreciation of their awesome power.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

It is an honor to be asked to write a foreword for this timely book, which assembles contributions from authorities working in the area of pathological nervous system cell death, and has been expertly edited by Vassilis Koliatsos and Rajiv Ratan. That the inap­ propriate demise of brain or spinal cord cells is at the root of many neurological diseases has been appreciated since the early days of microscopic neuropathology, but it has only been in the last decade or so that pervasive therapeutic nihilism has lifted. In the journey of medical progress, we have reached the shores of a marvelous new land. Three major scientific thrusts in particular have converged to produce the press of ideas covered here. First, burgeoning information about the fundamental nature of central nervous system cell--(;ell signaling, both the fast signaling mediated by conventional neu­ rotransmitters and the usually slower signaling mediated by neuromodulators and growth factors. A central theme emerging in recent years has been the duality of these signaling mechanisms, which serve the nervous system in health, but which can become the very mediators of neuronal or glial cell degeneration in disease settings. Glutamate-mediated neurotransmission and excitotoxicity have been the defining and best-studied examples, but many other examples have also emerged. Second, delineation of the molecular under­ pinnings of programmed cell death, and an appreciation of their awesome power.

More books from Humana Press

Cover of the book Euthanasia is Not the Answer by
Cover of the book Sleep Disorders by
Cover of the book Handbook of Clinical Nutrition and Stroke by
Cover of the book Techniques in Cell Cycle Analysis by
Cover of the book Vitamin D and the Lung by
Cover of the book Guide to Signal Pathways in Immune Cells by
Cover of the book Enzymatic Analysis by
Cover of the book Kernicterus by
Cover of the book Pancreatic Stem Cells by
Cover of the book Hematopathology by
Cover of the book Studies on Cardiovascular Disorders by
Cover of the book Sexual and Reproductive Neurorehabilitation by
Cover of the book Environmental Biotechnology by
Cover of the book Management of Prostate Cancer by
Cover of the book Human Cloning by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy