Cell-Extracellular Matrix Interactions in Cancer

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Cell-Extracellular Matrix Interactions in Cancer by , Springer New York
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Author: ISBN: 9781441908148
Publisher: Springer New York Publication: January 23, 2010
Imprint: Springer Language: English
Author:
ISBN: 9781441908148
Publisher: Springer New York
Publication: January 23, 2010
Imprint: Springer
Language: English

Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.

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Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.

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