Central Neurotransmitter Turnover

Kids, Natural World, Nonfiction, Reference & Language, Education & Teaching, Science & Nature, Science
Cover of the book Central Neurotransmitter Turnover by C. J. Pycock, P. V. Taberner, Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: C. J. Pycock, P. V. Taberner ISBN: 9781461597780
Publisher: Springer US Publication: December 6, 2012
Imprint: Springer Language: English
Author: C. J. Pycock, P. V. Taberner
ISBN: 9781461597780
Publisher: Springer US
Publication: December 6, 2012
Imprint: Springer
Language: English

The concept of chemical transmission in the central nervous system has taken some time to be generally accepted, but an increasing number of compounds are now being recognized as hav­ ing a transmitter role in the brain. The acetylcholine system was the first to be discovered in the periphery and its charac­ teristic features of storage of transmitter in vesicles in the nerve terminal, its electrically-evoked release and rapid extra­ neuronal breakdown were considered to be necessary criteria for any neurotransmitter candidate. The subsequent elucidation of the noradrenergic system made it apparent that rapid enzymatic breakdown was not essential for a released transmitter, and the possibility of high-affinity re-uptake processes became establ­ ished as an alternative means of terminating the synaptic actions of a transmitter. With the eventual acceptance of the amino acids as excitat­ ory or inhibitory transmitters, the requirement for a transmit­ ter to be present in a low concentration overall (although locally concentrated in specific terminals) also had to be discarded. This necessitated the additional concept of specif­ ic metabolic pools with different functions being located in different cells or within different regions of the same cell. Some localization of glutamate and aspartate remote from excit­ able membranes is clearly essential since their overall brain concentrations would be sufficient to maximally depolarize the majority of neurones in the brain. The concept of separate metabolic pools has been supported by stUdies on turnover rate (see Chapter 5).

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The concept of chemical transmission in the central nervous system has taken some time to be generally accepted, but an increasing number of compounds are now being recognized as hav­ ing a transmitter role in the brain. The acetylcholine system was the first to be discovered in the periphery and its charac­ teristic features of storage of transmitter in vesicles in the nerve terminal, its electrically-evoked release and rapid extra­ neuronal breakdown were considered to be necessary criteria for any neurotransmitter candidate. The subsequent elucidation of the noradrenergic system made it apparent that rapid enzymatic breakdown was not essential for a released transmitter, and the possibility of high-affinity re-uptake processes became establ­ ished as an alternative means of terminating the synaptic actions of a transmitter. With the eventual acceptance of the amino acids as excitat­ ory or inhibitory transmitters, the requirement for a transmit­ ter to be present in a low concentration overall (although locally concentrated in specific terminals) also had to be discarded. This necessitated the additional concept of specif­ ic metabolic pools with different functions being located in different cells or within different regions of the same cell. Some localization of glutamate and aspartate remote from excit­ able membranes is clearly essential since their overall brain concentrations would be sufficient to maximally depolarize the majority of neurones in the brain. The concept of separate metabolic pools has been supported by stUdies on turnover rate (see Chapter 5).

More books from Springer US

Cover of the book Perovskite Oxide for Solid Oxide Fuel Cells by C. J. Pycock, P. V. Taberner
Cover of the book Reemergence of Established Pathogens in the 21st Century by C. J. Pycock, P. V. Taberner
Cover of the book True Nature by C. J. Pycock, P. V. Taberner
Cover of the book Environment and Culture by C. J. Pycock, P. V. Taberner
Cover of the book Developing Your Career in Nursing by C. J. Pycock, P. V. Taberner
Cover of the book Risk Assessment Methods by C. J. Pycock, P. V. Taberner
Cover of the book Macroeconomic Analysis and Parametric Control of a National Economy by C. J. Pycock, P. V. Taberner
Cover of the book Intrinsic Motivation and Self-Determination in Human Behavior by C. J. Pycock, P. V. Taberner
Cover of the book Handbook of Clinical Sociology by C. J. Pycock, P. V. Taberner
Cover of the book How to Write a Successful Research Grant Application by C. J. Pycock, P. V. Taberner
Cover of the book Academic Scientists at Work by C. J. Pycock, P. V. Taberner
Cover of the book Global Warming by C. J. Pycock, P. V. Taberner
Cover of the book Medical Virology 10 by C. J. Pycock, P. V. Taberner
Cover of the book Heart Cell Coupling and Impulse Propagation in Health and Disease by C. J. Pycock, P. V. Taberner
Cover of the book Direct Myocardial Revascularization: History, Methodology, Technology by C. J. Pycock, P. V. Taberner
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy