Clinically Relevant Resistance in Cancer Chemotherapy

Nonfiction, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Clinically Relevant Resistance in Cancer Chemotherapy by , Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461511731
Publisher: Springer US Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461511731
Publisher: Springer US
Publication: December 6, 2012
Imprint: Springer
Language: English

Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long­ term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long­ term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.

More books from Springer US

Cover of the book Exchange and Deception: A Feminist Perspective by
Cover of the book Comparative, Maternal, and Epidemiologic Aspects by
Cover of the book Language and Language Acquisition by
Cover of the book Bacterial Infections of Humans by
Cover of the book Quantitative Methods in Bone Densitometry by
Cover of the book Practical Aspects of Computational Chemistry IV by
Cover of the book Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems by
Cover of the book Fiscal Federalism in Unitary States by
Cover of the book Pancreas Transplantation by
Cover of the book Drug Resistance in Cancer Therapy by
Cover of the book Behavioral Theories and Treatment of Anxiety by
Cover of the book Psychotraumatology by
Cover of the book Integrating Renewables in Electricity Markets by
Cover of the book Urolithiasis by
Cover of the book Metabolic Effects of Gonadal Hormones and Contraceptive Steroids by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy