Computational Methods for Processing and Analysis of Biological Pathways
Nonfiction, Computers, Advanced Computing, Computer Science, Science & Nature, Science, Biological Sciences
| Author: | Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos | ISBN: | 9783319538686 |
| Publisher: | Springer International Publishing | Publication: | March 9, 2017 |
| Imprint: | Springer | Language: | English |
| Author: | Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos |
| ISBN: | 9783319538686 |
| Publisher: | Springer International Publishing |
| Publication: | March 9, 2017 |
| Imprint: | Springer |
| Language: | English |
This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.
This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.
