Computational Neuroscience

Nonfiction, Science & Nature, Science, Biological Sciences, Computers
Cover of the book Computational Neuroscience by Kim L. Blackwell, Elsevier Science
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Kim L. Blackwell ISBN: 9780123979087
Publisher: Elsevier Science Publication: February 18, 2014
Imprint: Academic Press Language: English
Author: Kim L. Blackwell
ISBN: 9780123979087
Publisher: Elsevier Science
Publication: February 18, 2014
Imprint: Academic Press
Language: English

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. This volume brings together different aspects of, and approaches to, molecular and multi-scale modeling, with applications to a diverse range of neurological diseases.

Mathematical and computational modeling offers a powerful approach for examining the interaction between molecular pathways and ionic channels in producing neuron electrical activity. It is well accepted that non-linear interactions among diverse ionic channels can produce unexpected neuron behavior and hinder a deep understanding of how ion channel mutations bring about abnormal behavior and disease. Interactions with the diverse signaling pathways activated by G protein coupled receptors or calcium influx adds an additional level of complexity. Modeling is an approach to integrate myriad data sources into a cohesive and quantitative model in order to evaluate hypotheses about neuron function. In particular, a validated model developed using in vitro data allows simulations of the response to in vivo like spatio-temporal patterns of synaptic input. Incorporating molecular signaling pathways into an electrical model, allows a greater range of models to be developed, ones that can predict the response to pharmaceuticals, many of which target neuromodulator pathways.

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. This volume brings together different aspects of, and approaches to, molecular and multi-scale modeling, with applications to a diverse range of neurological diseases.

Mathematical and computational modeling offers a powerful approach for examining the interaction between molecular pathways and ionic channels in producing neuron electrical activity. It is well accepted that non-linear interactions among diverse ionic channels can produce unexpected neuron behavior and hinder a deep understanding of how ion channel mutations bring about abnormal behavior and disease. Interactions with the diverse signaling pathways activated by G protein coupled receptors or calcium influx adds an additional level of complexity. Modeling is an approach to integrate myriad data sources into a cohesive and quantitative model in order to evaluate hypotheses about neuron function. In particular, a validated model developed using in vitro data allows simulations of the response to in vivo like spatio-temporal patterns of synaptic input. Incorporating molecular signaling pathways into an electrical model, allows a greater range of models to be developed, ones that can predict the response to pharmaceuticals, many of which target neuromodulator pathways.

More books from Elsevier Science

Cover of the book Risk Management, Speculation, and Derivative Securities by Kim L. Blackwell
Cover of the book Seismic Waves and Rays in Elastic Media by Kim L. Blackwell
Cover of the book Geological Belts, Plate Boundaries, and Mineral Deposits in Myanmar by Kim L. Blackwell
Cover of the book Power Plant Instrumentation and Control Handbook by Kim L. Blackwell
Cover of the book Philosophy of Linguistics by Kim L. Blackwell
Cover of the book Chitosan Based Biomaterials Volume 1 by Kim L. Blackwell
Cover of the book Characterization of Liquids, Nano- and Microparticulates, and Porous Bodies using Ultrasound by Kim L. Blackwell
Cover of the book Foods, Nutrients and Food Ingredients with Authorised EU Health Claims by Kim L. Blackwell
Cover of the book Contemporary Aspects of Biomedical Research by Kim L. Blackwell
Cover of the book Russian Social Science Reader by Kim L. Blackwell
Cover of the book Digital Asset Ecosystems by Kim L. Blackwell
Cover of the book Fission, Fusion and The Energy Crisis by Kim L. Blackwell
Cover of the book Conceptual Design for Interactive Systems by Kim L. Blackwell
Cover of the book Fundamentals of Radiation and Chemical Safety by Kim L. Blackwell
Cover of the book Advances in Catalysis by Kim L. Blackwell
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy