Controlled Clinical Trials in Neurological Disease

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neuroscience, Neurology
Cover of the book Controlled Clinical Trials in Neurological Disease by , Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461314950
Publisher: Springer US Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461314950
Publisher: Springer US
Publication: December 6, 2012
Imprint: Springer
Language: English

The evaluation of the efficacy and safety of a clinical tool, be it a diagnostic technique, a preventive methodology, or a therapeutic intervention, is an im­ portant responsibility of physicians. The history of medicine is characterized by the authoritarianisms of teachers and of organizations giving way to the clinical experience of physicians; authoritarian dictum was replaced by case report and then by case series. As physicians learned to substitute the analysis of data for the inconsistencies of dictums and anecdotes, the problems of the case series as an investigative tool became more evident: patient selection criteria, measurements of outcome, significance of results, and extrapolation of conclusions to the community of patients. In response to these issues, the methodology of the controlled clinical trial has evolved and with it the instru­ ments of study design and of biostatistics as aids to study design and data analysis. The medical - surgical armamentarium has evolved from being dependent solely upon the observations and conclusions of a skilled clinician to being constructed upon the systematic collection and evaluation of data by a team of skilled clinicians and their statistical colleagues: this is the controlled clinical trial. During the past two decades, the evaluation of clinical approaches to pre­ vention and therapy has become particularly important to clinicians concerned with nervous system dysfunction. There has been and continues to be an explosion of information from the basic neurosciences and from the applica­ tion of biotechnology to the nervous system.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The evaluation of the efficacy and safety of a clinical tool, be it a diagnostic technique, a preventive methodology, or a therapeutic intervention, is an im­ portant responsibility of physicians. The history of medicine is characterized by the authoritarianisms of teachers and of organizations giving way to the clinical experience of physicians; authoritarian dictum was replaced by case report and then by case series. As physicians learned to substitute the analysis of data for the inconsistencies of dictums and anecdotes, the problems of the case series as an investigative tool became more evident: patient selection criteria, measurements of outcome, significance of results, and extrapolation of conclusions to the community of patients. In response to these issues, the methodology of the controlled clinical trial has evolved and with it the instru­ ments of study design and of biostatistics as aids to study design and data analysis. The medical - surgical armamentarium has evolved from being dependent solely upon the observations and conclusions of a skilled clinician to being constructed upon the systematic collection and evaluation of data by a team of skilled clinicians and their statistical colleagues: this is the controlled clinical trial. During the past two decades, the evaluation of clinical approaches to pre­ vention and therapy has become particularly important to clinicians concerned with nervous system dysfunction. There has been and continues to be an explosion of information from the basic neurosciences and from the applica­ tion of biotechnology to the nervous system.

More books from Springer US

Cover of the book Programmed Cell Death by
Cover of the book Current Ornithology by
Cover of the book Contemporary Nephrology by
Cover of the book Anxiety and Phobic Disorders by
Cover of the book GIS and Remote Sensing Applications in Biogeography and Ecology by
Cover of the book Basics of Software Engineering Experimentation by
Cover of the book Nursing in General Practice by
Cover of the book The Mobile Receptor Hypothesis by
Cover of the book Women, Work, and Health by
Cover of the book Basic and Clinical Tumor Immunology by
Cover of the book Social Deviance by
Cover of the book Biochemistry and Molecular Genetics of Cancer Metastasis by
Cover of the book Neuroanatomy for the Neuroscientist by
Cover of the book Handbook of Multimedia for Digital Entertainment and Arts by
Cover of the book Control Systems for Heating, Ventilating and Air Conditioning by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy