Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds
Nonfiction, Science & Nature, Science, Chemistry, Clinical, Organic
| Author: | Stacey L. McDonald | ISBN: | 9783319388786 |
| Publisher: | Springer International Publishing | Publication: | August 18, 2016 |
| Imprint: | Springer | Language: | English |
| Author: | Stacey L. McDonald |
| ISBN: | 9783319388786 |
| Publisher: | Springer International Publishing |
| Publication: | August 18, 2016 |
| Imprint: | Springer |
| Language: | English |
This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.
The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.
McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.
The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.
McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
