Cystic Fibrosis

Infection, Immunopathology, and Host Response

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology
Cover of the book Cystic Fibrosis by Richard B. Moss, Humana Press
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Richard B. Moss ISBN: 9781461204756
Publisher: Humana Press Publication: December 6, 2012
Imprint: Humana Language: English
Author: Richard B. Moss
ISBN: 9781461204756
Publisher: Humana Press
Publication: December 6, 2012
Imprint: Humana
Language: English

This work is concerned with Cystic Fibrosis (CF), the most common fatal genetic disease in the Caucasian population. The decade of the 1980s was one of spectacular progress in understanding the genetic and molecu­ lar basis of CF. The research breakthroughs of the decade began with the first fundamental insights, published in 1981-1983, into the basic cellular pathophysiology of CF with demonstrations of altered ion transport in spe­ cialized exocrine epithelial tissues (1-3). Research progress shifted into a triumph of "reverse genetics," using restriction-fragment-Iength polymor­ phism DNA technology (4), with the localization of the CF gene to a region of chromosome 7 (5-7). Understanding, accelerated by an explOSion of in vitro methodologies for epithelial cell culture and transformation, allowed and physiological studies (8-11); these focused, controlled biochemical with increasing precision, on the molecular pathology of distal steps in the regulatory pathways for epithelial ion transport (12-19). Finally, the "end of the beginning" occurred in late 1989 with one of the great achievements of molecular genetics, the isolation and cloning of the CF gene (20). As a result, we now have a CF gene product, the cystic fibrosis transmembrane regulator (CFfR), possessing predicted amino acid sequence, suggested tertiary structure, and possible transmembrane transport function (21). These amazing developments have set the stage for the next round of advances, which surely will include: 1.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This work is concerned with Cystic Fibrosis (CF), the most common fatal genetic disease in the Caucasian population. The decade of the 1980s was one of spectacular progress in understanding the genetic and molecu­ lar basis of CF. The research breakthroughs of the decade began with the first fundamental insights, published in 1981-1983, into the basic cellular pathophysiology of CF with demonstrations of altered ion transport in spe­ cialized exocrine epithelial tissues (1-3). Research progress shifted into a triumph of "reverse genetics," using restriction-fragment-Iength polymor­ phism DNA technology (4), with the localization of the CF gene to a region of chromosome 7 (5-7). Understanding, accelerated by an explOSion of in vitro methodologies for epithelial cell culture and transformation, allowed and physiological studies (8-11); these focused, controlled biochemical with increasing precision, on the molecular pathology of distal steps in the regulatory pathways for epithelial ion transport (12-19). Finally, the "end of the beginning" occurred in late 1989 with one of the great achievements of molecular genetics, the isolation and cloning of the CF gene (20). As a result, we now have a CF gene product, the cystic fibrosis transmembrane regulator (CFfR), possessing predicted amino acid sequence, suggested tertiary structure, and possible transmembrane transport function (21). These amazing developments have set the stage for the next round of advances, which surely will include: 1.

More books from Humana Press

Cover of the book Idiopathic Pulmonary Fibrosis by Richard B. Moss
Cover of the book Handbook of Clinical Nutrition and Stroke by Richard B. Moss
Cover of the book Retroviral Immunology by Richard B. Moss
Cover of the book Fluid and Electrolytes in Pediatrics by Richard B. Moss
Cover of the book Cortical Sensory Organization by Richard B. Moss
Cover of the book Clinical Allergy by Richard B. Moss
Cover of the book Hypothermia and Cerebral Ischemia by Richard B. Moss
Cover of the book Endocrinology of Critical Disease by Richard B. Moss
Cover of the book Molecular Typing in Bacterial Infections by Richard B. Moss
Cover of the book Anaphylaxis and Hypersensitivity Reactions by Richard B. Moss
Cover of the book Valvular Heart Disease by Richard B. Moss
Cover of the book The Centrosome by Richard B. Moss
Cover of the book Pediatric Interviewing by Richard B. Moss
Cover of the book Early Diagnosis and Treatment of Endocrine Disorders by Richard B. Moss
Cover of the book Essentials of Apoptosis by Richard B. Moss
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy