Development of Antibody-Based Therapeutics

Translational Considerations

Nonfiction, Health & Well Being, Medical, Specialties, Pharmacy, Medical Science, Pharmacology
Cover of the book Development of Antibody-Based Therapeutics by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781441959553
Publisher: Springer New York Publication: April 24, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781441959553
Publisher: Springer New York
Publication: April 24, 2012
Imprint: Springer
Language: English

Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.

More books from Springer New York

Cover of the book Handbook of Evidence-Based Substance Abuse Treatment in Criminal Justice Settings by
Cover of the book Chlorinated Solvent Source Zone Remediation by
Cover of the book Aesthetic Surgery of the Craniofacial Skeleton by
Cover of the book Sustainable Environmental Design in Architecture by
Cover of the book Isospectral Transformations by
Cover of the book Digital Fourier Analysis: Fundamentals by
Cover of the book Health Impact Assessment in the United States by
Cover of the book Computational Fluid Dynamics Applications in Food Processing by
Cover of the book Hunting and Imaging Comets by
Cover of the book Peritoneal Surgery by
Cover of the book Residue Reviews by
Cover of the book Activation and Detoxification Enzymes by
Cover of the book Traumatic Disorders of the Ankle by
Cover of the book Domestic Violence and Control by
Cover of the book Personal Peacefulness by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy