Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells

Mathematical Modeling and Experimental Observations

Nonfiction, Science & Nature, Technology, Material Science, Computers, Advanced Computing, Computer Science
Cover of the book Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells by Iman Tavassoly, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Iman Tavassoly ISBN: 9783319149622
Publisher: Springer International Publishing Publication: February 16, 2015
Imprint: Springer Language: English
Author: Iman Tavassoly
ISBN: 9783319149622
Publisher: Springer International Publishing
Publication: February 16, 2015
Imprint: Springer
Language: English

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

More books from Springer International Publishing

Cover of the book Economics of Grids, Clouds, Systems, and Services by Iman Tavassoly
Cover of the book Strategy in Airline Loyalty by Iman Tavassoly
Cover of the book Classroom-oriented Research by Iman Tavassoly
Cover of the book A Critical Analysis of Basic Income Experiments for Researchers, Policymakers, and Citizens by Iman Tavassoly
Cover of the book Practical Pharmacology for Alzheimer’s Disease by Iman Tavassoly
Cover of the book Geopolitics, Development, and National Security by Iman Tavassoly
Cover of the book Biological Soil Crusts: An Organizing Principle in Drylands by Iman Tavassoly
Cover of the book Molecular Basis for Mitochondrial Signaling by Iman Tavassoly
Cover of the book Riemannian Computing in Computer Vision by Iman Tavassoly
Cover of the book The Pathobiology of Breast Cancer by Iman Tavassoly
Cover of the book Frugal Innovation in Bioengineering for the Detection of Infectious Diseases by Iman Tavassoly
Cover of the book Reframing Information Architecture by Iman Tavassoly
Cover of the book Classical and Modern Controls with Microcontrollers by Iman Tavassoly
Cover of the book Advances in Reinforced Soil Structures by Iman Tavassoly
Cover of the book Domain Adaptation in Computer Vision Applications by Iman Tavassoly
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy