Eukaryotic Transcription Factors

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Biological Sciences, Biochemistry
Cover of the book Eukaryotic Transcription Factors by David Latchman, David S. Latchman, Elsevier Science
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Author: David Latchman, David S. Latchman ISBN: 9780080561035
Publisher: Elsevier Science Publication: July 28, 2010
Imprint: Academic Press Language: English
Author: David Latchman, David S. Latchman
ISBN: 9780080561035
Publisher: Elsevier Science
Publication: July 28, 2010
Imprint: Academic Press
Language: English

Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events.

  • Potential of transcription factors as therapeutic targets in human disease
  • Importance of histone modifications
  • Use of genome-based sequence analysis and high-throughput methods
  • Applications of the chromatin immunoprecipitation (ChIP) assay
  • Transcriptional elongation
  • Regulation by post-translational modifications
  • Regulatory networks and bioinformatics
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Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events.

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