Form and Function of Mammalian Lung: Analysis by Scientific Computing

Nonfiction, Health & Well Being, Medical, Medical Science, Physiology, Science & Nature, Science, Biological Sciences, Zoology
Cover of the book Form and Function of Mammalian Lung: Analysis by Scientific Computing by Andres Kriete, Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Andres Kriete ISBN: 9783642722202
Publisher: Springer Berlin Heidelberg Publication: March 7, 2013
Imprint: Springer Language: English
Author: Andres Kriete
ISBN: 9783642722202
Publisher: Springer Berlin Heidelberg
Publication: March 7, 2013
Imprint: Springer
Language: English

1.1 Overview The precise knowledge of the three-dimensional (3-D) assembly of biological structures is still in its origin. As an example, a widely accepted concept and common belief of the structure of the airway network oflung is that of a regular, dichotomous branching pattern, also known as the trumpet model. This model, first introduced by Weibel in 1963, is often used in clinical and physiological applications. However, if this concept of dichotomy is used to model lung, a shape is obtained that is quite different from a real lung. As a matter of fact, many previous quantitative morphological and stereological investigations of lung did not concentrate on the spatial aspect of lung morphology but delivered data in a more statistical fashion. Accordingly, the functional behavior predicted by such a model becomes questionable and indeed, the morphometrically predicted lung capacity exceeds the physiological required capacity by a factor of 1.3 up to a factor of2. This problem has also been termed a paradox, as discussed by Weibel in 1983. In the rare cases where descriptive models of the mammalian bronchial tree exist, monopodial in small mammals, dichotomous in larger ones, the understanding of the historical and/or functional reasons for size-related changes in the general design is not explainable. This investigation is trying to overcome this gap by computer modeling and functional simulation.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

1.1 Overview The precise knowledge of the three-dimensional (3-D) assembly of biological structures is still in its origin. As an example, a widely accepted concept and common belief of the structure of the airway network oflung is that of a regular, dichotomous branching pattern, also known as the trumpet model. This model, first introduced by Weibel in 1963, is often used in clinical and physiological applications. However, if this concept of dichotomy is used to model lung, a shape is obtained that is quite different from a real lung. As a matter of fact, many previous quantitative morphological and stereological investigations of lung did not concentrate on the spatial aspect of lung morphology but delivered data in a more statistical fashion. Accordingly, the functional behavior predicted by such a model becomes questionable and indeed, the morphometrically predicted lung capacity exceeds the physiological required capacity by a factor of 1.3 up to a factor of2. This problem has also been termed a paradox, as discussed by Weibel in 1983. In the rare cases where descriptive models of the mammalian bronchial tree exist, monopodial in small mammals, dichotomous in larger ones, the understanding of the historical and/or functional reasons for size-related changes in the general design is not explainable. This investigation is trying to overcome this gap by computer modeling and functional simulation.

More books from Springer Berlin Heidelberg

Cover of the book Cross Mentoring by Andres Kriete
Cover of the book Carbon Emissions in China by Andres Kriete
Cover of the book Essence of a Manager by Andres Kriete
Cover of the book Diabetes 1x1 by Andres Kriete
Cover of the book Atlas of Tumors of the Facial Skeleton by Andres Kriete
Cover of the book Understanding Verbal Art by Andres Kriete
Cover of the book Human Quality Management by Andres Kriete
Cover of the book Modelling Soil Erosion by Water by Andres Kriete
Cover of the book Underwater Acoustic Networking Techniques by Andres Kriete
Cover of the book Proof of Therapeutical Effectiveness of Nootropic and Vasoactive Drugs by Andres Kriete
Cover of the book Mitochondrial Genetics and Cancer by Andres Kriete
Cover of the book Sandostatin® in the Treatment of Acromegaly by Andres Kriete
Cover of the book Nonlinear Analysis of Gas-Water/Oil-Water Two-Phase Flow in Complex Networks by Andres Kriete
Cover of the book P3HT Revisited – From Molecular Scale to Solar Cell Devices by Andres Kriete
Cover of the book Urban Innovation and Upgrading in China Shanty Towns by Andres Kriete
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy