Fragment-based Drug Discovery

Lessons and Outlook

Nonfiction, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Fragment-based Drug Discovery by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Wiley
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ISBN: 9783527683628
Publisher: Wiley Publication: December 2, 2015
Imprint: Wiley-VCH Language: English
Author: Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
ISBN: 9783527683628
Publisher: Wiley
Publication: December 2, 2015
Imprint: Wiley-VCH
Language: English

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.

The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.

The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

More books from Wiley

Cover of the book The Completely Revised Handbook of Coaching by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book The Art of Critical Making by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Raising Baby Green by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Solvent Effects in Chemistry by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Free Space Optical Systems Engineering by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Licensed to Profit by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book CompTIA IT Fundamentals (ITF+) Study Guide by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Measurement While Drilling by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book A Companion to Mediterranean History by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Handbook of Veterinary Communication Skills by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book The Family Therapy Treatment Planner, with DSM-5 Updates, 2nd Edition by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Clinical Atlas of Small Animal Cytology by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Industrial Microbiology by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book The Triumph of Politics by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Cover of the book Mauerwerk Kalender 2019 by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy