Frontiers in Drug Discovery: Erythropoietic Stimulating Agents - Volume 1

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Hematology, Medical Science, Biochemistry
Cover of the book Frontiers in Drug Discovery: Erythropoietic Stimulating Agents - Volume 1 by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva, Bentham Science Publishers
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva ISBN: 9781608057474
Publisher: Bentham Science Publishers Publication: July 19, 2013
Imprint: Bentham E-Books Language: English
Author: Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
ISBN: 9781608057474
Publisher: Bentham Science Publishers
Publication: July 19, 2013
Imprint: Bentham E-Books
Language: English
The development of new erythropoietic stimulating agents (ESAs) has significantly increased in recent years. Researchers are focused on different and interesting concepts, namely, methods to increase half-life of erythropoietin (EPO), finding different routes of administration and new ESA or modified EPO molecules. Scientific literature presents evidence that EPO has other effects beyond erythropoietic stimulation. These pleiotropic effects of EPO appear to result from the existence of two different EPO receptors (EPOR) with different affinities for EPO. The discovery of new EPO actions beyond the hematopoietic system has opened a new field of investigation with these agents. Several molecules have been developed to present the protective action, without the activation of the hematopoietic system. These agents can be potentially used in several diseases of the brain/central and peripheral nervous system, eye, heart and kidney. This volume of Frontiers in Drug Discovery includes a revision of articles on erythropoiesis and EPO gene regulation, microRNAs and their potential contribution to the development of new therapeutic strategies, animal models for studying kidney disease-associated anemia as well as benefits/risks of ESA therapy. The biological effects of new ESA molecules, heparin-binding erythropoietin and of pHBSP, and the potential applications of ESA, are also elicited in this volume.This volume is, therefore, a useful reference for medicinal chemists and hematologists interested in drug development and medicine related to ESAs.
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
The development of new erythropoietic stimulating agents (ESAs) has significantly increased in recent years. Researchers are focused on different and interesting concepts, namely, methods to increase half-life of erythropoietin (EPO), finding different routes of administration and new ESA or modified EPO molecules. Scientific literature presents evidence that EPO has other effects beyond erythropoietic stimulation. These pleiotropic effects of EPO appear to result from the existence of two different EPO receptors (EPOR) with different affinities for EPO. The discovery of new EPO actions beyond the hematopoietic system has opened a new field of investigation with these agents. Several molecules have been developed to present the protective action, without the activation of the hematopoietic system. These agents can be potentially used in several diseases of the brain/central and peripheral nervous system, eye, heart and kidney. This volume of Frontiers in Drug Discovery includes a revision of articles on erythropoiesis and EPO gene regulation, microRNAs and their potential contribution to the development of new therapeutic strategies, animal models for studying kidney disease-associated anemia as well as benefits/risks of ESA therapy. The biological effects of new ESA molecules, heparin-binding erythropoietin and of pHBSP, and the potential applications of ESA, are also elicited in this volume.This volume is, therefore, a useful reference for medicinal chemists and hematologists interested in drug development and medicine related to ESAs.

More books from Bentham Science Publishers

Cover of the book Anti-Angiogenesis Drug Discovery and Development Volume: 3 by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Similarity Measures for Face Recognition by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Frontiers in Medicinal Chemistry Volume 9 by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Congenital Toxoplasmosis in Humans and Domestic Animals by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Frontiers in Natural Product Chemistry Volume: 2 by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Medicinal Chemistry - Fusion of Traditional and Western Medicine: Second Edition by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Topics in Anti-Cancer Research Volume: 4 by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Frontiers in Antimicrobial Agents Volume: 1 by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Advances in Physicochemical Properties of Biopolymers: Part 2 by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Novel Developments in Pharmaceutical and Biomedical Analysis by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Recent Advances in Biotechnology Volume: 1 by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Advances in Organic Synthesis (Volume 8) by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book The Sun-Climate Connection Over the Last Millennium Facts and Questions Volume: 1 by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Comparative Bioacoustics by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
Cover of the book Intellectual Property Basic Manual for Researchers in Universities by Elísio Manuel de Sousa Costa, Flávio Reis, Alice Santos-Silva
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy