Heteroaromatic Lipoxin A4 Analogues
Synthesis and Biological Evaluation
Nonfiction, Science & Nature, Science, Chemistry, Organic, Biological Sciences, Biochemistry
| Author: | Colm Duffy | ISBN: | 9783642246326 |
| Publisher: | Springer Berlin Heidelberg | Publication: | January 10, 2012 |
| Imprint: | Springer | Language: | English |
| Author: | Colm Duffy |
| ISBN: | 9783642246326 |
| Publisher: | Springer Berlin Heidelberg |
| Publication: | January 10, 2012 |
| Imprint: | Springer |
| Language: | English |
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
