Heterogeneity in Asthma

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Medical Science, Physiology
Cover of the book Heterogeneity in Asthma by , Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461486039
Publisher: Springer US Publication: July 8, 2014
Imprint: Humana Language: English
Author:
ISBN: 9781461486039
Publisher: Springer US
Publication: July 8, 2014
Imprint: Humana
Language: English

Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling.  These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response.  Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease.  An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma.  This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma.  As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. ​ 

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling.  These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response.  Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease.  An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma.  This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma.  As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. ​ 

More books from Springer US

Cover of the book The Unnoticed Majority in Psychiatric Inpatient Care by
Cover of the book SWAT Teams by
Cover of the book The Human Face by
Cover of the book Fungal Infection in the Intensive Care Unit by
Cover of the book Cerebral Sinus Thrombosis by
Cover of the book Computational Subsurface Hydrology by
Cover of the book Direct Myocardial Revascularization: History, Methodology, Technology by
Cover of the book Sensors Based on Nanostructured Materials by
Cover of the book The Biological Revolution by
Cover of the book The Sex Imperative by
Cover of the book Essays in Production, Project Planning and Scheduling by
Cover of the book Behavior, Health, and Environmental Stress by
Cover of the book Modernization of Traditional Food Processes and Products by
Cover of the book Ventricular Fibrillation and Sudden Coronary Death by
Cover of the book Total Materials Management by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy