Human Hematopoiesis in SCID Mice

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Science & Nature, Science, Other Sciences, Molecular Biology
Cover of the book Human Hematopoiesis in SCID Mice by , Springer Berlin Heidelberg
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Author: ISBN: 9783662220085
Publisher: Springer Berlin Heidelberg Publication: November 21, 2013
Imprint: Springer Language: English
Author:
ISBN: 9783662220085
Publisher: Springer Berlin Heidelberg
Publication: November 21, 2013
Imprint: Springer
Language: English

This book presents essential information on the use of the immunodeficient C.B.-17 SCID/SCID mouse for studying human hematopoiesis in vivo. Because of the lack of both humoral and cellular immunity, this mouse can be a unique host for implantation of human hematopoietic tissue using different methods. In the first section, in vivo development of human hematopoietic stem cells and differentiation of human T cells are described. In addition, the effects of growth factors and toxic agents of human hematopoiesis are described. The second section contains chapters in which the human immune responses in the SCID mouse are reviewed. The third section covers SCID mouse models to study human infectious diseases, leukemias and genetic disorders.

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This book presents essential information on the use of the immunodeficient C.B.-17 SCID/SCID mouse for studying human hematopoiesis in vivo. Because of the lack of both humoral and cellular immunity, this mouse can be a unique host for implantation of human hematopoietic tissue using different methods. In the first section, in vivo development of human hematopoietic stem cells and differentiation of human T cells are described. In addition, the effects of growth factors and toxic agents of human hematopoiesis are described. The second section contains chapters in which the human immune responses in the SCID mouse are reviewed. The third section covers SCID mouse models to study human infectious diseases, leukemias and genetic disorders.

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