Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors

Nonfiction, Science & Nature, Science, Other Sciences, Nanostructures, Chemistry, Analytic
Cover of the book Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors by Maximilian Oberleitner, Springer International Publishing
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Author: Maximilian Oberleitner ISBN: 9783319453842
Publisher: Springer International Publishing Publication: September 26, 2017
Imprint: Springer Language: English
Author: Maximilian Oberleitner
ISBN: 9783319453842
Publisher: Springer International Publishing
Publication: September 26, 2017
Imprint: Springer
Language: English

This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research.

The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design

principles and elucidates the boundary conditions of the new sensors.

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This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research.

The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design

principles and elucidates the boundary conditions of the new sensors.

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