Modelling the Short QT Syndrome Gene Mutations

And Their Role in Cardiac Arrhythmogenesis

Nonfiction, Science & Nature, Science, Biological Sciences, Biophysics, Cytology
Cover of the book Modelling the Short QT Syndrome Gene Mutations by Ismail Adeniran, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Ismail Adeniran ISBN: 9783319072005
Publisher: Springer International Publishing Publication: June 11, 2014
Imprint: Springer Language: English
Author: Ismail Adeniran
ISBN: 9783319072005
Publisher: Springer International Publishing
Publication: June 11, 2014
Imprint: Springer
Language: English

The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases.

The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as “outstanding.”

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases.

The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as “outstanding.”

More books from Springer International Publishing

Cover of the book Complex Systems Design & Management by Ismail Adeniran
Cover of the book Solar Photovoltaic System Applications by Ismail Adeniran
Cover of the book Indigenous Pacific Approaches to Climate Change by Ismail Adeniran
Cover of the book Understanding Flood Preparedness by Ismail Adeniran
Cover of the book Osteoporosis Rehabilitation by Ismail Adeniran
Cover of the book Latin American Heritage by Ismail Adeniran
Cover of the book Common Diagnostic Pitfalls in Thyroid Cytopathology by Ismail Adeniran
Cover of the book Vasculitis in Clinical Practice by Ismail Adeniran
Cover of the book The Puzzle of Perceptual Justification by Ismail Adeniran
Cover of the book Aquatic Microbial Ecology and Biogeochemistry: A Dual Perspective by Ismail Adeniran
Cover of the book Cardiac Rehabilitation Manual by Ismail Adeniran
Cover of the book Human Interface and the Management of Information. Information in Applications and Services by Ismail Adeniran
Cover of the book Myocardial Perfusion Imaging - Beyond the Left Ventricle by Ismail Adeniran
Cover of the book Mobile Electric Vehicles by Ismail Adeniran
Cover of the book Computational Biomechanics for Medicine by Ismail Adeniran
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy