Molecular Dynamics Analyses of Prion Protein Structures

The Resistance to Prion Diseases Down Under

Nonfiction, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Molecular Dynamics Analyses of Prion Protein Structures by Jiapu Zhang, Springer Singapore
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Jiapu Zhang ISBN: 9789811088155
Publisher: Springer Singapore Publication: July 20, 2018
Imprint: Springer Language: English
Author: Jiapu Zhang
ISBN: 9789811088155
Publisher: Springer Singapore
Publication: July 20, 2018
Imprint: Springer
Language: English

Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational” diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.

Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Sträussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.

Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-β structure PrP peptides are well studied.   

This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational” diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.

Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Sträussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.

Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-β structure PrP peptides are well studied.   

This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

More books from Springer Singapore

Cover of the book State-of-the-Art and Future Directions of Smart Learning by Jiapu Zhang
Cover of the book Simulations for Design and Manufacturing by Jiapu Zhang
Cover of the book Small-Sided and Conditioned Games in Soccer Training by Jiapu Zhang
Cover of the book Nanoelectronic Materials and Devices by Jiapu Zhang
Cover of the book Dynamic Analysis and Design of Offshore Structures by Jiapu Zhang
Cover of the book A Polymer Cochlear Electrode Array: Atraumatic Deep Insertion, Tripolar Stimulation, and Long-Term Reliability by Jiapu Zhang
Cover of the book Cognitive Science and Artificial Intelligence by Jiapu Zhang
Cover of the book Making a Difference Through Marketing by Jiapu Zhang
Cover of the book Sustainable Agriculture towards Food Security by Jiapu Zhang
Cover of the book Applications and Techniques in Information Security by Jiapu Zhang
Cover of the book Progress in Intelligent Computing Techniques: Theory, Practice, and Applications by Jiapu Zhang
Cover of the book Advances in Data and Information Sciences by Jiapu Zhang
Cover of the book Subdivision Surface Modeling Technology by Jiapu Zhang
Cover of the book Advances in Cognitive Neurodynamics (V) by Jiapu Zhang
Cover of the book The Story of Indian Manufacturing by Jiapu Zhang
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy