Morphofunctional Aspects of Tumor Microcirculation

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Morphofunctional Aspects of Tumor Microcirculation by Domenico Ribatti, Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Domenico Ribatti ISBN: 9789400749368
Publisher: Springer Netherlands Publication: September 28, 2012
Imprint: Springer Language: English
Author: Domenico Ribatti
ISBN: 9789400749368
Publisher: Springer Netherlands
Publication: September 28, 2012
Imprint: Springer
Language: English

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

More books from Springer Netherlands

Cover of the book Clinical Learning and Teaching Innovations in Nursing by Domenico Ribatti
Cover of the book Sciences and Cultures by Domenico Ribatti
Cover of the book Advanced Technologies, Embedded and Multimedia for Human-centric Computing by Domenico Ribatti
Cover of the book Ecology and Behaviour of the African Buffalo by Domenico Ribatti
Cover of the book Human and Nature Minding Automation by Domenico Ribatti
Cover of the book Pediatric Palliative Care: Global Perspectives by Domenico Ribatti
Cover of the book Theory and Experiment by Domenico Ribatti
Cover of the book Leibniz: Representation, Continuity and the Spatiotemporal by Domenico Ribatti
Cover of the book Polypharmacy in Psychiatry Practice, Volume I by Domenico Ribatti
Cover of the book The Impact of Nitrogen Deposition on Natural and Semi-Natural Ecosystems by Domenico Ribatti
Cover of the book Yearbook of Morphology 1995 by Domenico Ribatti
Cover of the book Translocal Ruralism by Domenico Ribatti
Cover of the book The Biological Basis of Schizophrenia by Domenico Ribatti
Cover of the book Information Technology in Educational Management by Domenico Ribatti
Cover of the book Corporate Taxation in the Netherlands Antilles by Domenico Ribatti
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy