Morphofunctional Aspects of Tumor Microcirculation

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Morphofunctional Aspects of Tumor Microcirculation by Domenico Ribatti, Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Domenico Ribatti ISBN: 9789400749368
Publisher: Springer Netherlands Publication: September 28, 2012
Imprint: Springer Language: English
Author: Domenico Ribatti
ISBN: 9789400749368
Publisher: Springer Netherlands
Publication: September 28, 2012
Imprint: Springer
Language: English

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

More books from Springer Netherlands

Cover of the book Methods and Procedures for Building Sustainable Farming Systems by Domenico Ribatti
Cover of the book Nation-Building and History Education in a Global Culture by Domenico Ribatti
Cover of the book Positive Relationships by Domenico Ribatti
Cover of the book Liquid Crystalline Semiconductors by Domenico Ribatti
Cover of the book Research, Action and Policy: Addressing the Gendered Impacts of Climate Change by Domenico Ribatti
Cover of the book Dutch Studies by Domenico Ribatti
Cover of the book IT Security Management by Domenico Ribatti
Cover of the book Neutrality and Theory of Law by Domenico Ribatti
Cover of the book Climate Change, Justice and Sustainability by Domenico Ribatti
Cover of the book Semantics of Genitive Objects in Russian by Domenico Ribatti
Cover of the book Textbook of Healthcare Ethics by Domenico Ribatti
Cover of the book Edward Channing and the Great Work by Domenico Ribatti
Cover of the book Chlorine and the Environment by Domenico Ribatti
Cover of the book Managing the Future of Southeast Asia's Valuable Tropical Rainforests by Domenico Ribatti
Cover of the book Dialectical Theory of Meaning by Domenico Ribatti
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy