MRI Contrast Agents

From Molecules to Particles

Nonfiction, Science & Nature, Technology, Material Science, Engineering, Health & Well Being, Medical
Cover of the book MRI Contrast Agents by Céline Henoumont, Dimitri Stanicki, Sébastien Boutry, Estelle Lipani, Sarah Belaid, Robert N. Muller, Luce Vander Elst, Sophie Laurent, Springer Singapore
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Author: Céline Henoumont, Dimitri Stanicki, Sébastien Boutry, Estelle Lipani, Sarah Belaid, Robert N. Muller, Luce Vander Elst, Sophie Laurent ISBN: 9789811025297
Publisher: Springer Singapore Publication: November 3, 2016
Imprint: Springer Language: English
Author: Céline Henoumont, Dimitri Stanicki, Sébastien Boutry, Estelle Lipani, Sarah Belaid, Robert N. Muller, Luce Vander Elst, Sophie Laurent
ISBN: 9789811025297
Publisher: Springer Singapore
Publication: November 3, 2016
Imprint: Springer
Language: English

This book describes the multiple aspects of (i) preparation of the magnetic core, (ii) the stabilization with different coatings, (iii) the physico-chemical characterization and (iv) the vectorization to obtain specific nanosystems. Several bio-applications are also presented in this book. In the early days of Magnetic Resonance Imaging (MRI), paramagnetic ions were proposed as contrast agents to enhance the diagnostic quality of MR images. Since then, academic and industrial efforts have been devoted to the development of new and more efficient molecular, supramolecular and nanoparticular systems. Old concepts and theories, like paramagnetic relaxation, were revisited and exploited, leading to new scientific tracks. With their high relaxivity payload, the superparamagnetic nanoparticles are very appealing in the context of molecular imaging but challenges are still numerous: absence of toxicity, specificity, ability to cross the biological barriers, etc. 

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This book describes the multiple aspects of (i) preparation of the magnetic core, (ii) the stabilization with different coatings, (iii) the physico-chemical characterization and (iv) the vectorization to obtain specific nanosystems. Several bio-applications are also presented in this book. In the early days of Magnetic Resonance Imaging (MRI), paramagnetic ions were proposed as contrast agents to enhance the diagnostic quality of MR images. Since then, academic and industrial efforts have been devoted to the development of new and more efficient molecular, supramolecular and nanoparticular systems. Old concepts and theories, like paramagnetic relaxation, were revisited and exploited, leading to new scientific tracks. With their high relaxivity payload, the superparamagnetic nanoparticles are very appealing in the context of molecular imaging but challenges are still numerous: absence of toxicity, specificity, ability to cross the biological barriers, etc. 

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