Multistate GTPase Control Co-translational Protein Targeting

Nonfiction, Science & Nature, Science, Chemistry, Organic, Biological Sciences, Biochemistry
Cover of the book Multistate GTPase Control Co-translational Protein Targeting by Xin Zhang, Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Xin Zhang ISBN: 9781441978080
Publisher: Springer US Publication: September 29, 2011
Imprint: Springer Language: English
Author: Xin Zhang
ISBN: 9781441978080
Publisher: Springer US
Publication: September 29, 2011
Imprint: Springer
Language: English

Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.

Written while completing graduate work at California Institute of Technology.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.

Written while completing graduate work at California Institute of Technology.

More books from Springer US

Cover of the book Advances in Parapsychological Research by Xin Zhang
Cover of the book Parallel Processing in the Visual System by Xin Zhang
Cover of the book Hypertension and the Heart by Xin Zhang
Cover of the book Semiconductor Optical Modulators by Xin Zhang
Cover of the book Elder Abuse by Xin Zhang
Cover of the book Gastric Cytoprotection by Xin Zhang
Cover of the book CAPD/CCPD in Children by Xin Zhang
Cover of the book Efficacy, Agency, and Self-Esteem by Xin Zhang
Cover of the book The Philosophy of Taxation and Public Finance by Xin Zhang
Cover of the book Panels for Transportation Planning by Xin Zhang
Cover of the book Risk Management in Blood Transfusion: The Virtue of Reality by Xin Zhang
Cover of the book Infantile Spasms by Xin Zhang
Cover of the book Clinical Disorders of Memory by Xin Zhang
Cover of the book Safety with Cryogenic Fluids by Xin Zhang
Cover of the book Psychological Approaches to Generalized Anxiety Disorder by Xin Zhang
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy