Novel (Trans)dermal Drug Delivery Strategies

Micro- and Nano-scale Assessments

Nonfiction, Science & Nature, Science, Physics, Radiation, Health & Well Being, Medical, Allied Health Services, Medical Technology
Cover of the book Novel (Trans)dermal Drug Delivery Strategies by Garvie-Cook Hazel, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Garvie-Cook Hazel ISBN: 9783319289014
Publisher: Springer International Publishing Publication: January 23, 2016
Imprint: Springer Language: English
Author: Garvie-Cook Hazel
ISBN: 9783319289014
Publisher: Springer International Publishing
Publication: January 23, 2016
Imprint: Springer
Language: English

This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.

More books from Springer International Publishing

Cover of the book Creativity, Technology & Education: Exploring their Convergence by Garvie-Cook Hazel
Cover of the book The Theoretical and Practical Dimensions of Regionalism in East Asia by Garvie-Cook Hazel
Cover of the book Dynamics and Characterization of Composite Quantum Systems by Garvie-Cook Hazel
Cover of the book Iconicity and Abduction by Garvie-Cook Hazel
Cover of the book British Domestic Synchronous Clocks 1930-1980 by Garvie-Cook Hazel
Cover of the book Understanding Gaia by Garvie-Cook Hazel
Cover of the book Smartphone-Based Human Activity Recognition by Garvie-Cook Hazel
Cover of the book Physicochemical Theory of Effective Stress in Soils by Garvie-Cook Hazel
Cover of the book Practitioner’s Guide to Functional Behavioral Assessment by Garvie-Cook Hazel
Cover of the book On the Move to Meaningful Internet Systems: OTM 2018 Workshops by Garvie-Cook Hazel
Cover of the book Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals by Garvie-Cook Hazel
Cover of the book The Vegetation of the Iberian Peninsula by Garvie-Cook Hazel
Cover of the book University Cricket and Emerging Adulthood by Garvie-Cook Hazel
Cover of the book Oncodynamics: Effects of Cancer Cells on the Body by Garvie-Cook Hazel
Cover of the book Introduction to Random Matrices by Garvie-Cook Hazel
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy