Phenotypes and Genotypes
The Search for Influential Genes
Nonfiction, Science & Nature, Science, Biological Sciences, Physiology, Computers, Advanced Computing, Computer Science
| Author: | Małgorzata Bogdan, David Ramsey, Florian Frommlet | ISBN: | 9781447153108 |
| Publisher: | Springer London | Publication: | February 12, 2016 |
| Imprint: | Springer | Language: | English |
| Author: | Małgorzata Bogdan, David Ramsey, Florian Frommlet |
| ISBN: | 9781447153108 |
| Publisher: | Springer London |
| Publication: | February 12, 2016 |
| Imprint: | Springer |
| Language: | English |
This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.
This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.
