Prolactin

Physiology, Pharmacology and Clinical Findings

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Endocrinology & Metabolism, Medical Science, Pharmacology
Cover of the book Prolactin by E. Flückiger, E. DelPozo, K. v. Werder, Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: E. Flückiger, E. DelPozo, K. v. Werder ISBN: 9783642817212
Publisher: Springer Berlin Heidelberg Publication: December 6, 2012
Imprint: Springer Language: English
Author: E. Flückiger, E. DelPozo, K. v. Werder
ISBN: 9783642817212
Publisher: Springer Berlin Heidelberg
Publication: December 6, 2012
Imprint: Springer
Language: English

Lactogenic hormone activity was first observed in bovine pituitary extracts by Stricker and Griiter in 1928, working in Bouin's laboratory in Strasbourg. Since that time prolactin has been shown to exist in anterior pituitary extracts of almost all vertebrate species investigated. Although its biology was extensively studied in many mammalian species, the existence of prolactin in the human was generally doubted, despite the positive evidence produced by such researchers as Pasteels. This can partly be explained by the fact that human growth hormone isolated in 1961, is itself a potent lactogen, in contrast to nonprimate growth hormones, and is present in the normal human pituitary in much greater amounts than prolactin. As a result there was a lag of nearly 10 years until prolactin was unanimously accepted as a hormone of the human pituitary, separate from human growth hormone. In 1970 new bioassay techniques permitted the demonstration of prolactin bioactivity in the serum of postpartum women and galactorrhea patients, and chromatographic methods led to the isolation and purification of human prolactin allowing the establishment of a specific radioimmunoassay for this hormone. This opened the road to the understanding of prolactin physiology and pathophysiology in the human, which has revolutionized clinical neuroendocrinology and reproductive endocrinology. Particularly hyperprolactinemia has turned out to be one of the most common endocrine syndromes.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Lactogenic hormone activity was first observed in bovine pituitary extracts by Stricker and Griiter in 1928, working in Bouin's laboratory in Strasbourg. Since that time prolactin has been shown to exist in anterior pituitary extracts of almost all vertebrate species investigated. Although its biology was extensively studied in many mammalian species, the existence of prolactin in the human was generally doubted, despite the positive evidence produced by such researchers as Pasteels. This can partly be explained by the fact that human growth hormone isolated in 1961, is itself a potent lactogen, in contrast to nonprimate growth hormones, and is present in the normal human pituitary in much greater amounts than prolactin. As a result there was a lag of nearly 10 years until prolactin was unanimously accepted as a hormone of the human pituitary, separate from human growth hormone. In 1970 new bioassay techniques permitted the demonstration of prolactin bioactivity in the serum of postpartum women and galactorrhea patients, and chromatographic methods led to the isolation and purification of human prolactin allowing the establishment of a specific radioimmunoassay for this hormone. This opened the road to the understanding of prolactin physiology and pathophysiology in the human, which has revolutionized clinical neuroendocrinology and reproductive endocrinology. Particularly hyperprolactinemia has turned out to be one of the most common endocrine syndromes.

More books from Springer Berlin Heidelberg

Cover of the book Indium by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Advances in Cryptology – ASIACRYPT 2016 by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Conditionals and Modularity in General Logics by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Waves and Tidal Flat Ecosystems by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book IT-gestütztes Ressourcen- und Energiemanagement by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Metallogeny of Tin by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Cardiovascular MRI in Congenital Heart Disease by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Standards in der Medienproduktion by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Deformation and Flow of Polymeric Materials by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Grundlagen der Naturwissenschaftsdidaktik by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Computation and Asymptotics by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Signal Transduction: Pathways, Mechanisms and Diseases by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Radiopathology of Organs and Tissues by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book Behavioral Neurobiology of Anxiety and Its Treatment by E. Flückiger, E. DelPozo, K. v. Werder
Cover of the book The Tyranny of Uncertainty by E. Flückiger, E. DelPozo, K. v. Werder
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy