Protein Carbonylation

Principles, Analysis, and Biological Implications

Nonfiction, Science & Nature, Science, Physics, Spectrum Analysis
Cover of the book Protein Carbonylation by , Wiley
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781119374954
Publisher: Wiley Publication: May 15, 2017
Imprint: Wiley Language: English
Author:
ISBN: 9781119374954
Publisher: Wiley
Publication: May 15, 2017
Imprint: Wiley
Language: English

Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology.

In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur.

The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed.

  • Oxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems
  • Mass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described
  • Aging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation
  • Direct oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways
  • Emerging methods for characterizing carbonylated protein networks and affected metabolic pathways
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology.

In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur.

The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed.

More books from Wiley

Cover of the book Isotopic Analysis by
Cover of the book XFEM Fracture Analysis of Composites by
Cover of the book Der Turm und die Brücke by
Cover of the book Geometry: 1,001 Practice Problems For Dummies (+ Free Online Practice) by
Cover of the book Spanish Grammar For Dummies by
Cover of the book Rapid Midwifery by
Cover of the book The Science Quest by
Cover of the book Gas-Phase Synthesis of Nanoparticles by
Cover of the book Nanomaterials for 2D and 3D Printing by
Cover of the book Saving the Earth as a Career by
Cover of the book Nikon D40 / D40x Digital Field Guide by
Cover of the book Wiley Not-for-Profit GAAP 2011 by
Cover of the book Marketing for Dummies by
Cover of the book Laptops For Seniors For Dummies by
Cover of the book The Ivy Portfolio by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy