Protein Quality Control in Neurodegenerative Diseases
Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Specialties, Internal Medicine, Neuroscience
| Author: | ISBN: | 9783642279287 | |
| Publisher: | Springer Berlin Heidelberg | Publication: | December 13, 2012 |
| Imprint: | Springer | Language: | English |
| Author: | |
| ISBN: | 9783642279287 |
| Publisher: | Springer Berlin Heidelberg |
| Publication: | December 13, 2012 |
| Imprint: | Springer |
| Language: | English |
The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
