Recent Advances in Transthyretin Evolution, Structure and Biological Functions

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Endocrinology & Metabolism, Medical Science, Physiology
Cover of the book Recent Advances in Transthyretin Evolution, Structure and Biological Functions by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642006463
Publisher: Springer Berlin Heidelberg Publication: August 9, 2009
Imprint: Springer Language: English
Author:
ISBN: 9783642006463
Publisher: Springer Berlin Heidelberg
Publication: August 9, 2009
Imprint: Springer
Language: English

Since its ?rst description in 1942 in both serum and cerebrospinal ?uid, transthyretin (TTR) has had an eventful history, including changes in name from “prealbumin” to “thyroxine-binding prealbumin” to “transthyretin” as knowledge increased about its functions. TTR is synthesised in a wide range of tissues in humans and other eutherian mammals: the liver, choroid plexus (blood- cerebrospinal ?uid barrier), retinal pigment epithelium of the eye, pancreas, intestine and meninges. However, its sites of synthesis are more restricted in other vertebrates. This implies that the number of tissues synthesising TTR during vertebrate evolution has increased, and raises questions about the selection pressures governing TTR synthesis. TTR is most widely known as a distributor of thyroid hormones. In addition, TTR binds retinol-binding protein, which binds retinol. In this way, TTR is also involved with retinoid distribution. More recently, TTR has been demonstrated to bind a wide variety of endocrine disruptors including drugs, pollutants, industrial compounds, heavy metals, and some naturally occurring plant ?avonoids. These not only interfere with thyroid hormone delivery in the body, but also transport such endocrine disruptors into the brain, where they have the potential to accumulate.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Since its ?rst description in 1942 in both serum and cerebrospinal ?uid, transthyretin (TTR) has had an eventful history, including changes in name from “prealbumin” to “thyroxine-binding prealbumin” to “transthyretin” as knowledge increased about its functions. TTR is synthesised in a wide range of tissues in humans and other eutherian mammals: the liver, choroid plexus (blood- cerebrospinal ?uid barrier), retinal pigment epithelium of the eye, pancreas, intestine and meninges. However, its sites of synthesis are more restricted in other vertebrates. This implies that the number of tissues synthesising TTR during vertebrate evolution has increased, and raises questions about the selection pressures governing TTR synthesis. TTR is most widely known as a distributor of thyroid hormones. In addition, TTR binds retinol-binding protein, which binds retinol. In this way, TTR is also involved with retinoid distribution. More recently, TTR has been demonstrated to bind a wide variety of endocrine disruptors including drugs, pollutants, industrial compounds, heavy metals, and some naturally occurring plant ?avonoids. These not only interfere with thyroid hormone delivery in the body, but also transport such endocrine disruptors into the brain, where they have the potential to accumulate.

More books from Springer Berlin Heidelberg

Cover of the book Business Modelling in the Dynamic Digital Space by
Cover of the book Arthroscopic Management of Ulnar Pain by
Cover of the book The China Continental Scientific Drilling Project by
Cover of the book Advances in Political Economy by
Cover of the book Heart Rate and Rhythm by
Cover of the book Study Nurse / Studienassistenz by
Cover of the book Psychological Theories from a Structuralist Point of View by
Cover of the book Centromere by
Cover of the book 5S als Basis des kontinuierlichen Verbesserungsprozesses by
Cover of the book Kommentar zur Musterberufsordnung der deutschen Ärzte (MBO) by
Cover of the book Advances in Wind Energy Conversion Technology by
Cover of the book Magnetophotonics by
Cover of the book TMLR Management of Coronary Artery Diseases by
Cover of the book Infection Control in Intensive Care Units by Selective Decontamination by
Cover of the book Transport Development in Asian Megacities by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy