Role of Capsaicin in Oxidative Stress and Cancer
Nonfiction, Health & Well Being, Medical, Specialties, Oncology, Science & Nature, Science
| Author: | ISBN: | 9789400763173 | |
| Publisher: | Springer Netherlands | Publication: | April 23, 2013 |
| Imprint: | Springer | Language: | English |
| Author: | |
| ISBN: | 9789400763173 |
| Publisher: | Springer Netherlands |
| Publication: | April 23, 2013 |
| Imprint: | Springer |
| Language: | English |
This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
