Solid State Characterization of Pharmaceuticals

Nonfiction, Science & Nature, Science, Chemistry, Analytic
Cover of the book Solid State Characterization of Pharmaceuticals by , Wiley
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Author: ISBN: 9781119970170
Publisher: Wiley Publication: March 31, 2011
Imprint: Wiley-Blackwell Language: English
Author:
ISBN: 9781119970170
Publisher: Wiley
Publication: March 31, 2011
Imprint: Wiley-Blackwell
Language: English

The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties.

This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field.

The following topics are included:

  • Physical properties and processes
  • Thermodynamics
  • Intellectual guidance
  • X-ray diffraction
  • Spectroscopy Microscopy
  • Particle sizing
  • Mechanical properties
  • Vapour sorption
  • Thermal analysis & Calorimetry
  • Polymorph prediction
  • Form selection
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The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties.

This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field.

The following topics are included:

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