Spheroids in Cancer Research

Methods and Perspectives

Nonfiction, Health & Well Being, Medical, Medical Science, Biochemistry, Specialties, Oncology
Cover of the book Spheroids in Cancer Research by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642823404
Publisher: Springer Berlin Heidelberg Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9783642823404
Publisher: Springer Berlin Heidelberg
Publication: December 6, 2012
Imprint: Springer
Language: English

Malignant growth of cells is often characterized by disorganization of tissue structure, abnormal blood vessel development, and insuffi­ cient vascular supply. As a consequence, the cancer cells grow in a three-dimensional pattern in atypical microenvironments which include physical, chemical, and nutritional stresses. Necrosis often develops some distance away from the blood vessels. In association with an inherent instability in malignant cell populations, and also because of the changing micromilieu, significant cellular heteroge­ neity emerges with regard to various phenotypic characteristics. Both biological behavior and responses to therapeutic agents can be affected. A variety of in vitro and in vivo experimental models exist for research on properties of cancer cells during growth. The multicell spheroid model was developed as a system of intermediate complexity in which three dimensional growth of cells enhances cell-cell interactions and creates micro environments that simulate the conditions in intervascular microregions of tumors or microme­ tastatic foci. Spheroids may change their cellular characteristics with changing environments during growth. These can be studied under controlled conditions in vitro. Interest in details of experimental methods for this model system stimulated the organization of the First International Conference in Rochester, NY in 1980, the Proceedings of which were summarized in Cancer Research in 1981. Since then there has been a rapid increase in the use of this model system, and increased research on the significance of cell-cell and cell-microenvironment interactions in biology in general.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Malignant growth of cells is often characterized by disorganization of tissue structure, abnormal blood vessel development, and insuffi­ cient vascular supply. As a consequence, the cancer cells grow in a three-dimensional pattern in atypical microenvironments which include physical, chemical, and nutritional stresses. Necrosis often develops some distance away from the blood vessels. In association with an inherent instability in malignant cell populations, and also because of the changing micromilieu, significant cellular heteroge­ neity emerges with regard to various phenotypic characteristics. Both biological behavior and responses to therapeutic agents can be affected. A variety of in vitro and in vivo experimental models exist for research on properties of cancer cells during growth. The multicell spheroid model was developed as a system of intermediate complexity in which three dimensional growth of cells enhances cell-cell interactions and creates micro environments that simulate the conditions in intervascular microregions of tumors or microme­ tastatic foci. Spheroids may change their cellular characteristics with changing environments during growth. These can be studied under controlled conditions in vitro. Interest in details of experimental methods for this model system stimulated the organization of the First International Conference in Rochester, NY in 1980, the Proceedings of which were summarized in Cancer Research in 1981. Since then there has been a rapid increase in the use of this model system, and increased research on the significance of cell-cell and cell-microenvironment interactions in biology in general.

More books from Springer Berlin Heidelberg

Cover of the book Pediatric Oncology Nursing by
Cover of the book Intellectual Property and Free Trade Agreements in the Asia-Pacific Region by
Cover of the book Histological Typing of Endocrine Tumours by
Cover of the book Zweihundert Jahre Entwicklung der Theoretischen Chemie im deutschsprachigen Raum by
Cover of the book Practical Gas Chromatography by
Cover of the book The Natural Environment and the Biogeochemical Cycles by
Cover of the book Beidhändige Führung by
Cover of the book CSR und Recht by
Cover of the book Personalentwicklung in Pflege- und Gesundheitseinrichtungen by
Cover of the book Speciation of Metals in Water, Sediment and Soil Systems by
Cover of the book Polyhydroxyalkanoates from Palm Oil: Biodegradable Plastics by
Cover of the book X-Ray Absorption Spectroscopy of Semiconductors by
Cover of the book Pictorial Law by
Cover of the book Biosystems Engineering I by
Cover of the book Photo-oxidants, Acidification and Tools: Policy Applications of EUROTRAC Results by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy