Stress-Induced Mutagenesis

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Stress-Induced Mutagenesis by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461462804
Publisher: Springer New York Publication: March 12, 2013
Imprint: Springer Language: English
Author:
ISBN: 9781461462804
Publisher: Springer New York
Publication: March 12, 2013
Imprint: Springer
Language: English

The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes.

This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes.

This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.

More books from Springer New York

Cover of the book Stearoyl-CoA Desaturase Genes in Lipid Metabolism by
Cover of the book Sleep and Combat-Related Post Traumatic Stress Disorder by
Cover of the book Physiocracy, Antiphysiocracy and Pfeiffer by
Cover of the book Measuring Technology and Mechatronics Automation in Electrical Engineering by
Cover of the book Resource Management for Multimedia Services in High Data Rate Wireless Networks by
Cover of the book Vertebrates and Invertebrates of European Cities:Selected Non-Avian Fauna by
Cover of the book Degradation of Implant Materials by
Cover of the book Reviews of Environmental Contamination and Toxicology by
Cover of the book Percutaneous Venous Blood Sampling in Endocrine Diseases by
Cover of the book The Mathematics of Paul Erdős I by
Cover of the book Advances in Entrepreneurial Finance by
Cover of the book The Innovation Butterfly by
Cover of the book Exploring Frontiers of the Mind-Brain Relationship by
Cover of the book Technology and Consumption by
Cover of the book Pediatric Genetics and Inborn Errors of Metabolism by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy