Structural and Evolutionary Genomics

Natural Selection in Genome Evolution

Nonfiction, Science & Nature, Science, Biological Sciences, Biochemistry, Ecology
Cover of the book Structural and Evolutionary Genomics by Giorgio Bernardi, Elsevier Science
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Author: Giorgio Bernardi ISBN: 9780080461878
Publisher: Elsevier Science Publication: December 19, 2005
Imprint: Elsevier Science Language: English
Author: Giorgio Bernardi
ISBN: 9780080461878
Publisher: Elsevier Science
Publication: December 19, 2005
Imprint: Elsevier Science
Language: English

Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a "regional" control is exerted by natural selection (essentially negative or purifying selection). A "neo-selectionist" model is proposed for genome evolution.

· Summarizes the existing knowledge on genome organization and evolution in a self-contained
book
· Discusses important open problem, without refraining from criticism whenever
appropriate

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a "regional" control is exerted by natural selection (essentially negative or purifying selection). A "neo-selectionist" model is proposed for genome evolution.

· Summarizes the existing knowledge on genome organization and evolution in a self-contained
book
· Discusses important open problem, without refraining from criticism whenever
appropriate

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