Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells

Nonfiction, Science & Nature, Science, Biological Sciences, Cytology, Other Sciences, Molecular Biology
Cover of the book Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells by Xiaoyang Zhao, Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Xiaoyang Zhao ISBN: 9789401788199
Publisher: Springer Netherlands Publication: May 19, 2014
Imprint: Springer Language: English
Author: Xiaoyang Zhao
ISBN: 9789401788199
Publisher: Springer Netherlands
Publication: May 19, 2014
Imprint: Springer
Language: English

Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential for regenerative medicine to treat complicated disorders, like Parkinson’s disease and spinal cord injury. There will also be many applications in drug development. However, several roadblocks, such as safety issues and low efficiency of pluripotent stem cell (PSC) line derivation need to be resolved before their clinical application. This thesis focuses on these two areas, so as to find methods to overcome the limitation. It covers deriving embryonic stem cells (ESCs) from several different species and reports an efficient system to generate induced pluripotent stem cells (iPSCs), and the first iPSC mice in the world. The results in this thesis confirm that somatic cells can be fully reprogrammed with the four Yamanaka factors. In addition, we have found that the Dlk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications and increase the current low induction efficiency of their production.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential for regenerative medicine to treat complicated disorders, like Parkinson’s disease and spinal cord injury. There will also be many applications in drug development. However, several roadblocks, such as safety issues and low efficiency of pluripotent stem cell (PSC) line derivation need to be resolved before their clinical application. This thesis focuses on these two areas, so as to find methods to overcome the limitation. It covers deriving embryonic stem cells (ESCs) from several different species and reports an efficient system to generate induced pluripotent stem cells (iPSCs), and the first iPSC mice in the world. The results in this thesis confirm that somatic cells can be fully reprogrammed with the four Yamanaka factors. In addition, we have found that the Dlk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications and increase the current low induction efficiency of their production.

More books from Springer Netherlands

Cover of the book What Counts as Mathematics? by Xiaoyang Zhao
Cover of the book Rationality in Science and Politics by Xiaoyang Zhao
Cover of the book Analyzing and Theorizing the Dynamics of the Workplace Incivility Crisis by Xiaoyang Zhao
Cover of the book Nanotechnology in the Security Systems by Xiaoyang Zhao
Cover of the book Beef Production from Different Dairy Breeds and Dairy Beef Crosses by Xiaoyang Zhao
Cover of the book Nutrient Indicator Models for Determining Biologically Relevant Levels by Xiaoyang Zhao
Cover of the book Analytic Philosophy and Phenomenology by Xiaoyang Zhao
Cover of the book Managing Urban Water Supply by Xiaoyang Zhao
Cover of the book Kant as Philosophical Anthropologist by Xiaoyang Zhao
Cover of the book Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas by Xiaoyang Zhao
Cover of the book Materials Science for Structural Geology by Xiaoyang Zhao
Cover of the book Theory of Legal Science by Xiaoyang Zhao
Cover of the book Legal Validity by Xiaoyang Zhao
Cover of the book Neoclassical Economic Theory, 1870 to 1930 by Xiaoyang Zhao
Cover of the book On Criminalization by Xiaoyang Zhao
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy