Targeting the Wnt Pathway in Cancer

Nonfiction, Health & Well Being, Medical, Specialties, Oncology, Medical Science, Pharmacology
Cover of the book Targeting the Wnt Pathway in Cancer by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781441980236
Publisher: Springer New York Publication: January 25, 2011
Imprint: Springer Language: English
Author:
ISBN: 9781441980236
Publisher: Springer New York
Publication: January 25, 2011
Imprint: Springer
Language: English

Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

More books from Springer New York

Cover of the book Anti-Poverty Psychology by
Cover of the book Textbook of Refractive Laser Assisted Cataract Surgery (ReLACS) by
Cover of the book Geometry of Hypersurfaces by
Cover of the book A Case-Based Guide to Clinical Endocrinology by
Cover of the book Posttranslational Protein Modifications in the Reproductive System by
Cover of the book Gender and Sexual Identity by
Cover of the book Global Climate Change and Public Health by
Cover of the book The New Paradigm of Immunity to Tuberculosis by
Cover of the book Imaging Methods for Novel Materials and Challenging Applications, Volume 3 by
Cover of the book Kidney Transplantation by
Cover of the book Crossroads between Innate and Adaptive Immunity III by
Cover of the book Phytochemicals, Signal Transduction, and Neurological Disorders by
Cover of the book Bioactive Polyphenols from Wine Grapes by
Cover of the book Translational Criminology and Counterterrorism by
Cover of the book Textbook of Tinnitus by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy