The Role of Microenvironment in the Control of Tumor Angiogenesis

Nonfiction, Health & Well Being, Medical, Specialties, Pathology, Oncology
Cover of the book The Role of Microenvironment in the Control of Tumor Angiogenesis by Domenico Ribatti, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Domenico Ribatti ISBN: 9783319278209
Publisher: Springer International Publishing Publication: February 9, 2016
Imprint: Springer Language: English
Author: Domenico Ribatti
ISBN: 9783319278209
Publisher: Springer International Publishing
Publication: February 9, 2016
Imprint: Springer
Language: English

This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis.

Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes.

In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli.

Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors.

In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis.

New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.     

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis.

Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes.

In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli.

Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors.

In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis.

New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.     

More books from Springer International Publishing

Cover of the book Applied Mathematical Analysis: Theory, Methods, and Applications by Domenico Ribatti
Cover of the book Engineering Multi-Agent Systems by Domenico Ribatti
Cover of the book Beauty, Ugliness and the Free Play of Imagination by Domenico Ribatti
Cover of the book Experiences from Ground, Coastal and Transitional Water Quality Monitoring by Domenico Ribatti
Cover of the book Holocaust Education in Primary Schools in the Twenty-First Century by Domenico Ribatti
Cover of the book Computer Vision – ECCV 2016 Workshops by Domenico Ribatti
Cover of the book Neurological Disorders in the Arab World by Domenico Ribatti
Cover of the book Progress in Life Cycle Assessment by Domenico Ribatti
Cover of the book Intelligent Methods for Cyber Warfare by Domenico Ribatti
Cover of the book Under Observation: The Interplay Between eHealth and Surveillance by Domenico Ribatti
Cover of the book Technical Safety – An Attribute of Quality by Domenico Ribatti
Cover of the book Breast Cancer Stem Cells & Therapy Resistance by Domenico Ribatti
Cover of the book Portfolio Selection Using Multi-Objective Optimisation by Domenico Ribatti
Cover of the book Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations by Domenico Ribatti
Cover of the book Periodic Feedback Stabilization for Linear Periodic Evolution Equations by Domenico Ribatti
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy